Animal Models of Demyelination and ¹H-Magnetic Resonance Spectroscopy.
- Author:
Han Byul CHO
1
;
Suji LEE
;
Shinwon PARK
;
Ilhyang KANG
;
Jiyoung MA
;
Hyeonseok S JEONG
;
Jieun E KIM
;
Sujung YOON
;
In Kyoon LYOO
;
Soo Mee LIM
;
Jungyoon KIM
Author Information
1. The Brain Institute, University of Utah, Salt Lake City, UT, USA.
- Publication Type:Review
- Keywords:
Proton magnetic resonance spectroscopy;
Demyelination;
Animal models
- MeSH:
Animals*;
Aspartic Acid;
Autoimmune Diseases;
Brain;
Butyric Acid;
Choline;
Creatine;
Demyelinating Diseases*;
Encephalomyelitis;
Glutamic Acid;
Humans;
Models, Animal*;
Multiple Sclerosis;
Myelin Sheath;
Neurons;
Pathologic Processes;
Proton Magnetic Resonance Spectroscopy;
Rodentia;
Spectrum Analysis*
- From:Journal of the Korean Society of Biological Psychiatry
2017;24(1):1-9
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The proton magnetic resonance spectroscopy (¹H-MRS) is a tool used to detect concentrations of brain metabolites such as N-acetyl aspartate, choline, creatine, glutamate, and gamma-amino butyric acid (GABA). It has been widely used because it does not require additional devices other than the conventional magnetic resonance scanner and coils. Demyelination, or the neuronal damage due to loss of myelin sheath, is one of the common pathologic processes in many diseases including multiple sclerosis, leukodystrophy, encephalomyelitis, and other forms of autoimmune diseases. Rodent models mimicking human demyelinating diseases have been induced by using virus (e.g., Theiler's murine encephalomyelitis virus) or toxins (e.g., cuprizon or lysophosphatidyl choline). This review is an overview of the MRS findings on brain metabolites in demyelination with a specific focus on rodent models.
