A Prospective Study on an Association between Apolipoprotein E epsilon4 and Cognitive Change in Community-Dwelling Elders with Alzheimer's Disease.
- Author:
Min Sung KANG
1
;
Seok Woo MOON
Author Information
1. Department of Psychiatry, Konkuk University School of Medicine, Chungju, Korea. hessem@kku.ac.kr
- Publication Type:Original Article
- Keywords:
Alzheimer's disease;
Apolipoprotein E;
CERAD-K;
Prospective study
- MeSH:
Aged;
Alleles;
Alzheimer Disease*;
Apolipoproteins E;
Apolipoproteins*;
Humans;
Male;
Memory;
Memory, Episodic;
Prospective Studies*
- From:Journal of the Korean Society of Biological Psychiatry
2013;20(3):104-110
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: The aim of this study was to examine the prospective impact of the apolipoprotein E (APOE) epsilon4 on cognitive performance in the community-dwelling elderly individuals with Alzheimer's disease (AD). METHODS: The total number of subjects was 30 (12 men and 18 women) who were diagnosed with AD from a Korean project of "Early Detection of Dementia". People aged 65-85 years were included in the analysis. The eight neuropsychological domains from the Korean version of Consortium to Establish a Registry of Alzheimer's Disease (CERAD-K) were conducted to test subjects. They have been followed at 24-month intervals with the same assessments at each interval. Their cognitive performance at 2 year intervals was compared by the occurrence of the APOE epsilon4. RESULTS: The impact of epsilon4 allele was significant in the Word List Memory Test (WLMT, F = 4.345, df = 1, p = 0.021) and Word List Recall Test (WLRT, F = 5.569, df = 1, p = 0.033). CONCLUSIONS: The APOE epsilon4 allele was significantly correlated especially with verbal episodic memory domain in community-dwelling elders diagnosed with AD.
