Effect of Pretreatment of (-)-3-PPP on the Haloperidol-Induced Extracellular Dopamine Concentraions in the Nucleus Accumbens of Rats.
- Author:
Young Chul CHUNG
;
Hong Bae EUN
;
Ik Keun HWANG
;
Tae Won PARK
- Publication Type:Original Article
- Keywords:
Haloperidol;
Dopamine;
Nucleus accumbens
- MeSH:
Animals;
Dopamine*;
Haloperidol;
Limbic System;
Nucleus Accumbens*;
Rats*
- From:Journal of the Korean Society of Biological Psychiatry
2001;8(1):79-84
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: To investigate the effects of (-)-3-PPP(0.5, 2, and 10mg/kg, s.c.) and haloperidol(0.1, 0.5, and 2mg/kg, s.c.) on the extracellular dopamine concentrations, and the effect of pretreatment with (-)-3-PPP(2mg/kg) on the haloperidol(2mg/kg)-induced extracellular dopamine concentrations in the nucleus accumbens(NAS) of free moving rats. METHODS: Dopamine levels in dialysate were determined with high pressure liquid chromatography(HPLC) with electrochemical detection(ECD). RESULTS: (1) (-)-3-PPP had dual actions depending on the doses : at 2mg/kg, it decreased and at 10mg/kg, increased extracellular dopamine concentrations ; (2) haloperidol at all doses increased dopamine levels with higher dose having a greater icrease ; and (3) pretreatment of (-)-3-PPP reduced the increase in dopamine levels elicited by acute treatment with haloperidol. CONCLUSIONS: These findings suggest that pretreatment of (-)-3-PPP in low dose could accelerate the onset of therapeutic effect of haloperidol by diminishing the haloperidol-induced dopamine release in the limbic system.
