The Association between the Dopamine D1 Receptor Genotype and Treatment Response in Korean Schizophrenic Patients.
- Author:
Jong Woo PAIK
;
Min Soo LEE
;
Choong Soon RHEE
;
Dong Ju LIM
;
Won Hun HAM
- Publication Type:Original Article
- Keywords:
Dopamine D1 receptor;
Receptor gene;
Schizophrenia;
Treatment response
- MeSH:
Antipsychotic Agents;
Diagnostic and Statistical Manual of Mental Disorders;
DNA;
Dopamine*;
Genotype*;
Humans;
Individuality;
Nucleotides;
Psychopathology;
Receptors, Dopamine;
Receptors, Dopamine D1*;
Schizophrenia
- From:Journal of the Korean Society of Biological Psychiatry
2001;8(1):106-110
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Dopamine receptors have been regarded as a strong candidate involved in etiology of schizophrenia and a target for various antipsychotic drugs. The purpose of our study was to investigate whether dopamine D1 receptor(DRD1) gene polymorphisms would predict the treatment response to antipsychotics in schizophrenia. METHOD: One hundred thirty-four schizophrenic patients, who met DSM-IV criteria for schizophrenia were entered into a 48-week study. The psychopathology of the patients was assessed at baseline, 12th, 24th, 48th weeks of treatment by PANSS. Responders were defined by a 20% of the reduction in total PAnSS score at end point. The genomic DNA fragment corresponding to nucleotides of dopamine D1 receptor gene was amplified by polymerase chain reaction(PCR). RESULT: Neither allelic frequencies nor genotypes for dopamine D1 receptor differed significantly between responders and non-responders. Also, there was no difference of changes of PANSS scores among three genotype groups of the dopamine D1 receptor. CONCLUSION: Allelic variation in the dopamine D1 gene is not associated with individual differences in antipsychotic response.
