An Association Study of COMT Gene Polymorphism with Korean Alcoholism.
- Author:
Min Jung KIM
;
Byung Hwan YANG
;
Jung Sik LEE
;
Young Gyu CHA
;
Taek Kyu PARK
- Publication Type:Original Article
- Keywords:
Alcoholism;
Association;
COMT;
Polymorphism
- MeSH:
Alcoholics;
Alcoholism*;
Alleles;
Genotype;
Humans
- From:Journal of the Korean Society of Biological Psychiatry
2001;8(1):111-115
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
An association study with Korean alcoholic patients(n=50) and normal controls(n=53) was performed to find the relationship between catechol-O-methyltransferase(COMT) gene polymorphism and alcoholism using polymerase chain reaction-restriction fragment length polymorphism. When we compared the allele and genotype frequencies of Nla III COMT gene polymorphism in alcoholism and normal controls, there was no significant difference between two groups. Our results do not support an association between the Nla III polymorphism of COMT gene and alcoholism.
