Animal Models of Alzheimer's Dementia.
- Author:
Sung Il WOO
- Publication Type:Original Article
- MeSH:
Alzheimer Disease;
Amyloid;
Animals*;
Dementia*;
Mice;
Mice, Transgenic;
Models, Animal*;
Neurofibrillary Tangles;
Neurons;
Presenilins
- From:Journal of the Korean Society of Biological Psychiatry
1999;6(2):149-152
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Transgenic mice models of Alzheimer's disease were produced by overexpressing APP(amyloid precursor protein) mutant and presenilin mutant genes using the promotors that induced neuronal expression. The neuropathologies, electrophysiological changes and behavioral changes that were demonstrated in these transgenic mice model were amyloid changes, gliotic changes. A-beta increases, deficit in LTP(ling-term potentiation) and behavioral changes. Some or all of the above changes were found in each transgenic mice model. These models generally showed amyloid neuropathology but they usually lacked the neurofibrillary tangles. So, they can be regarded as partial models of Alzheimer's disease. The development of them is undoubtedly the great progress toward future research.
