Role of Serotonin in the Pathology and Treatment of Violence and Suicide.
- Author:
In Won CHUNG
- Publication Type:Original Article
- Keywords:
Suicide;
Serotonin;
Biologic marker
- MeSH:
Aggression;
Biomarkers;
Biology;
Brain;
Central Nervous System;
Cerebrospinal Fluid;
Fenfluramine;
Models, Genetic;
Neurotransmitter Agents;
Pathology*;
Prolactin;
Psychology;
Serotonin Uptake Inhibitors;
Serotonin*;
Suicide*;
Violence*
- From:Journal of the Korean Society of Biological Psychiatry
1997;4(2):188-193
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Along with psychosocial factors of suicide, biological backgrounds of suicide are explored by extensive works mostly on biological markers, neurobiological models, genetic bases, and relationship with aggression and violence. The biology of suicide confers on neurotransmitters in central nervous system exploring metabolites, receptor binding affinities, neuroen-docrine challenge tests in brain, cerebrospinal fluid, blood and etc. The major concerns with suicide are focused mainly on serotomin system: low CSF-5-HIAA concentration, higher 5-HT2 receptor binding, and blunt prolactin response to fenfluramine. Postmortem study, in vivo study, genetic contributions, and some other issues such as suicidal methods, serum cholesteral, alcohol, and selective serotonin reuptake inhibitors are reviewed and discussed.
