Failure to Support Associations of Neurotrophin-3(NT-3) Gene Polymorphism in Korean Schizophrenic Patients.
- Author:
Yu sang LEE
- Publication Type:Original Article
- Keywords:
Neurotrophin-3 (NT-3);
Dinucleotide repeat polymorphism;
Association study;
Schizophrenia
- MeSH:
Alleles;
Asian Continental Ancestry Group;
Base Pairing;
Dinucleotide Repeats;
Humans;
Japan;
Schizophrenia
- From:Journal of the Korean Society of Biological Psychiatry
1997;4(2):234-236
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Though initial report from Japan showed positive association of schizophrenia with dinucleotide repeat polymorphism in the NT-3 gene, subsequent studies showed mixed results. Therefore we conducted a replication study with Korean schizophrenics and matched controls who share similar ethnic background with Japanese population. The frequency of allele of dinucleotide repeat at 147 base pairs in the NT-3 gene was slightly increased, however, failed to reach statistical significance(X2=1.884, df=1, p<0.170) between the two groups. These findings do not support on association of NT-3 gene polymorphism with schizophrenia in Korean sample.
