Therapeutic Drug Monitoring(TDM) of Psychotropic Drugs.
- Author:
Byung Hwan YANG
- Publication Type:Original Article
- Keywords:
Therapeutic drug monitoring, TDM;
Psychotropic drug;
Drug concentration
- MeSH:
Antipsychotic Agents;
Carbamazepine;
Drug Interactions;
Lithium;
Pharmacokinetics;
Psychiatry;
Psychotropic Drugs*;
Valproic Acid
- From:Journal of the Korean Society of Biological Psychiatry
1998;5(1):56-65
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Clinicians can use therapeutic drug monitoring(TDM) to optimise dosage decisions with psychotropic drugs, in order to maximize efficacy and prevent toxicity, especially when individuals are nonresponsive to treatment or vulnerable to adverse reactions with standard doses because age, disease states or drug interactions. Currently therapeutic drug concentrations have been established for the TCA and lithium. There is also evidence for the usefulness of TDM with carbamazepine, valproic acid and some antipsychotic drugs. However for most psychotropic drugs this approach remains experimental. TDM-assisted psychiatric treatment is potentially useful and cost effective, particularly when applied by psychiatrists who are knowledgeable of pharmacokinetics and pharmacodynamics.
