Psychosis in Parkinson.
- Author:
Seong Beom KOH
;
Kun Woo PARK
;
Dae Hie LEE
- Publication Type:Original Article
- Keywords:
Levodopa-induced psychosis;
5-HT3 receptor antagonist on
- MeSH:
Adult;
Antipsychotic Agents;
Hallucinations;
Humans;
Levodopa;
Male;
Ondansetron;
Parkinson Disease;
Psychotic Disorders*;
Receptors, Serotonin, 5-HT3
- From:Journal of the Korean Society of Biological Psychiatry
1997;4(1):132-135
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Current treatment strategies for levodopa-induced psychosis in advanced Parkinson's disease have had limited success. Reduction or discontinuation of levodopa and coadministration with dopamine-blocking neuroleptics may attenuate the psychotic symptoms, but these strategies are associated with worsening of parkinsonian symptoms. Administration of 5-HT3 receptor antagonist ; ondansetron, a newer strategy to attenuate psychosis of Parkinson' disease without motor deterioration was introduced. A 41-year-old young-onset male, who was diagnosed as Parkinson's disease 7 years ago, was treated with levodopa therapy, and had levodopa-induced psychosis(delusion, hallucination, paranoid, insomnia). After trial of ondansetron, he showed improvement in the Brief Psychiatric Rating Scale(from 21 points to 9 points) in spite of increasing the dosage of levodopa. With ondansetron, we could increase the dosage of levodopa without psychotic complications(esp, hallucination), and he showed improvement in the motor fluctuation.
