A Study on Developing Computer Models of Neuropsychiatric Diseases.
- Author:
In Song KOH
;
Jeong Wook PARK
- Publication Type:Original Article
- Keywords:
Computer model;
Dementia;
Neural network;
Schizophrenia;
Synapse
- MeSH:
Computer Simulation*;
Dementia;
Memory;
Neuropsychiatry;
Schizophrenia;
Synapses
- From:Journal of the Korean Society of Biological Psychiatry
1999;6(1):12-20
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
In order to understand the pathogenesis and progression of some synaptic loss related neuropsychiatric diseases. We attempted to develop a computer model in this study. We made a simple autoassociative memory network remembering numbers, transformed it into a disease model by pruning synapses, and measured its memory performance as a function of synaptic deletion. Decline in performance was measured as amount of synaptic loss increases and its mode of declines is sudden or gradual according to the mode of synaptic pruning. The developed computer model demonstrated how synaptic loss could cause memory impairment through a series of computer simulations, and suggested a new way of research in neuropsychiatry.
