Association of Tardive Dyskinesia with Cognitive Deficit in Schizophrenia.
- Author:
Tae Seob JANG
;
Byoung Hoon OH
;
Jin Sook CHEON
- Publication Type:Original Article
- Keywords:
Schizophrenia;
Tardive dyskinesia;
Cognitive deficit
- MeSH:
Dopamine;
Dyskinesias;
Glutamate Dehydrogenase;
Humans;
Male;
Movement Disorders*;
Plasma;
Risk Factors;
Schizophrenia*
- From:Journal of the Korean Society of Biological Psychiatry
1999;6(1):89-95
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
To understand a mechanism of underlying cognitive deficit in schizophrenia, the risk factors, cognitive function, blood dopamine concentrations and glutamate dehydrogenase activities of male schizophrenics with tardive dyskinesia(N=30) were compared with those of schizophrenics without tardive dyskinesia(N=30). The result were as following ; 1) The age, duration of illness and duration of medication were significantly more in schizophrenics with tardive dyskinesia than schizophrenics without tardive dyskinesia(respectively p<0.005, p<0.0001, p<0.0001). 2)The scores of MMSE, TIQ, VIQ and PIQ were significantly lower in schizophrenics with tradive dyskinesia than schizophrenics without tardive dyskinesia(respectively p<0.0001). 3) plasma dopamine concentrations were tended to be higher, and serum glutamate dehydrogenase activities were tended to be lower in schizophrenics with tardive dyskinesia than schizophrenics without tardive dyskinesia. 4) The cognitive deficit seemed to be negatively correlated with duration of illness and duration of illness and duration of medication(respectively gamma=-0.496, gamma=-0.615).
