Basic Principles of Drug Interaction.
- Author:
Boe Gwun CHUN
- Publication Type:Original Article
- Keywords:
Drug-interaction;
Drug response variations
- MeSH:
Classification;
Drug Interactions*;
Drug Therapy;
Drug-Related Side Effects and Adverse Reactions
- From:Journal of the Korean Society of Biological Psychiatry
2000;7(1):3-13
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
There is nothing that is harmless ; the dose alone decides that something is no poison(Paracelsus. 1493-1541). So, in a point of view to maximize the therapeutic efficacy of drug therapy in a was that minimize the drug toxicity, the knowledges of the drug-interactions as well as the pharmacokinetic and pharmacodynamic principles of every therapeutic drug used in the medical clinic cannot be emphasized too much. Many drug interactions can be predicted if the pharmacokinetic properties, pharmacodynamic mechanisms of action of the interacting drugs are known and most adverse interactions can be avoided. In this paper, the clinical importance, classification, and general principles of clinical drug-interactions are presentated with a few explanatory examples.
