The use of Amantadine in Traumatic Brain Injury Patients.
- Author:
Han Yong JUNG
;
Yang Rae KIM
- Publication Type:Original Article
- Keywords:
Amantadine;
Dopamine agonist;
NMDA receptor antagonist;
Traumatic brain
- MeSH:
Amantadine*;
Brain;
Brain Injuries*;
Dopamine Agents;
Dopamine Agonists;
Humans;
Impulsive Behavior;
Memory, Short-Term;
Motivation;
N-Methylaspartate;
Neurons;
Problem Solving
- From:Journal of the Korean Society of Biological Psychiatry
2000;7(1):55-63
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Avariety of symptoms can occur following traumatic brain injury(TBI) or other types of acquired brain injury. These symptoms can include problems with short-term memory, attention, planning, problem solving, impulsivity, disinhibition, poor motivation, and other behavioral and cognitive deficit. These symptoms may respond to certain drugs, such as dopaminergic agents. Amantadine may protect patients from secondary neuronal damage after brain injury as a effects of NMDA receptor antagonists and may improve functioning of brain-injured patients as a dopaminergic agonist. Clinically, based on current evidence, amantadine may provide a potentially effective, safe, and inexpensive option for treating the cognitive, mood and behavioral disorders of individuals with brain injury. The rationales for using amantadine are discussed, and pertinent literatures are reviewed.
