A Case of Risperidone-induced Neuroleptic Malignant Syndrome.
- Author:
Hwa Yeon KANG
;
Yong Ku KIM
;
Min Soo LEE
- Publication Type:Original Article
- Keywords:
Risperidone;
Neuroleptic malignant syndrome
- MeSH:
Antipsychotic Agents;
Consciousness;
Fever;
Muscle Rigidity;
Neuroleptic Malignant Syndrome*;
Receptors, Dopamine D2;
Risperidone;
Serotonin
- From:Journal of the Korean Society of Biological Psychiatry
1998;5(1):138-141
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Neuroleptic malignant syndrome(NMS) is an uncommon but potentially fatal idiosyncratic reaction to neuroleptics, characterized by muscular rigidity, fever, autonomic dysfunction, and altered consciousness. The major theories to explain NMS is central dopaminergic blockade, but it is unclear. Risperidone is a new antipsychotic drug, a benzisoxazole derivative that blocks dopamine D2 receptor and serotonin type 2 receptor. The comparatively greater serotonin-blocking activity is believed to give risperidone the specific property of not causing any more extrapyramidal side effects than conventional antipsychotics at the optimal dose of 4-8mg/day. It is postulated that risperidone is unlikely to cause NMS. Here, we report a case of risperidone induced neuroleptic malignant syndrome.
