Prefrontal Cortex and Schizophrenia.
- Author:
Young Chul CHUNG
;
Hong Bae EUN
- Publication Type:Original Article
- Keywords:
Prfrontal cortex;
Schizophrenia;
Dopamine
- MeSH:
Dopamine;
Neurochemistry;
Neuroimaging;
Neurophysiology;
Neuropsychological Tests;
Neurosciences;
Neurotransmitter Agents;
Pathology;
Prefrontal Cortex*;
Schizophrenia*
- From:Journal of the Korean Society of Biological Psychiatry
1998;5(2):184-196
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
With a rapid development of neuroscience, the theories related to the pathophysiology of schizophrenia have been changed a lot from a simple hyperdopaminergic one to the various complicated ones. Among these, the theories regarding prefrontal cortex(PFC) pathology as a cause of schizophrenia are gaining more recognition as the results of neuroimaging and neuropsychological tests in schizophrenia consistently report abnormalities in PFC. Therefore, we first reviewed the unique characteristics of PFC in anatomy, neurochemistry and neurophysiology to enhance an understanding of those ones. Secondly, various neurotransmitter, neurodevelopmental and neural network theories of schizophrenia introduced recently were reviewed in terms of PFC pathology.
