An Association Study of COMT Gene Polymorphism with Korean Schizophrenics.
- Author:
En Sook SONG
;
Young Gyu CHAI
;
Byung Hwan YANG
;
Kang Kyu PARK
;
Dong Yul OH
;
Gil Sook KIM
;
Yu Sang LEE
;
Eun Soog AN
;
Jong Won KIM
;
Ihn Geun CHOI
- Publication Type:Original Article
- Keywords:
Schizophrenia;
Association;
COMT;
Polymorphism;
Alleles
- MeSH:
Alleles;
Genotype;
Schizophrenia
- From:Journal of the Korean Society of Biological Psychiatry
1998;5(2):210-214
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
An association study with Korean schizophrenic patients(N=84) and normal controls(N=87) was performed to find the relationship between catechol-o-methyltransferase(COMT) gene polymorphism and schizophrenia using polymerase chain reaction-restriction fragment length polymorphism. When we compared the allele and genotype frequencies of Bg/I COMT gene polymorphism in schizophrenics and normal controls, there was no significant difference between two groups. Our results do not support an association between the Bg/I polymorphism of COMT gene and schizophrenia.
