Association between Schizophrenia and the T102C Polymorphism of the 5-HT2A.
- Author:
Min Soo LEE
;
Jong Won NAM
;
Dong Il KWAK
- Publication Type:Original Article
- Keywords:
5-HT2A;
T102C polymorphism;
Schizophrenia
- MeSH:
Alleles;
DNA;
Gene Frequency;
Humans;
Polymerase Chain Reaction;
Psychopharmacology;
Receptor, Serotonin, 5-HT2A;
Schizophrenia*;
Serotonin;
Serotonin 5-HT2 Receptor Antagonists
- From:Journal of the Korean Society of Biological Psychiatry
1998;5(2):215-218
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The 5-HT2A receptor is of great interest for research into schizophrenia and psychopharmacology in light of the observation that schizophrenic patients has 5-HT cortical-subcortical imbalance and atypical antipsychotic clozpine has 5-HT2A antagonists properties. An significant association between schizophrenia and the T102C polymorphism of the gene for 5-HT2A receptor has been reported. In this study, we investigated an association between schizophrenia and the T102C polymorphism of the gene for 5-HT2A receptor in Korean schizophrenic patients. The subjects consisted of 139 schizophrenic patients and 88 normal controls. Genomic DNA was amplified by PCR and digested with MsPI. The uncutt product identified allele 1(nucleotide sequence TCT) ; digested products of 216bp and 156bp identified allele 2(nucleotide sequence TCC). The allele frequencies and the genotypic distribution of 5-HT2A receptor gene were not significantly different between schizophrenic patients and normal controls. Since allele frequencies of the T102C polymorphism may differ between individuals of different ethnic backgrounds, it needs to be conducted in an advanced research.
