Genetic Polymorphisms of Apolipoprotein E in Korean Schizophrenic Patients.
- Author:
Gwang Hyun CHO
1
;
Sang Geun CHUNG
;
Ik Keun HWANG
Author Information
1. Department of Psychiatry, College of Medicine, Chonbuk National University, Jeonju, Korea.
- Publication Type:Original Article
- Keywords:
Apolipoprotein E;
Schizophrenia;
Genotypes
- MeSH:
Alleles;
Apolipoproteins*;
Gene Frequency;
Genotype;
Humans;
Phenotype;
Polymerase Chain Reaction;
Polymorphism, Genetic*;
Schizophrenia
- From:Journal of the Korean Society of Biological Psychiatry
2003;10(2):116-120
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: Although polymorphisms of apolipoprotein E have been investigated in many neuropsychiatric disorders, results were controversial and even contradictory. The purpose of this study was to investigate the genotypes of apolipoprotein E in schizophrenia and healthy controls, and to compare them in two groups in terms of distribution of apolipoprotein E genotype and allele. METHOD: Using polymerase chain reaction and amplified refractory mutation system, apolipoprotein E genotypes were identified in 77 schizophrenics and 115 healthy control persons. RESULTS: The results were as follows 1) When genotypes of apolipoprotein E were classified into epsilon2/2, epsilon2/3, epsilon2/4, epsilon3/3, epsilon3/4, epsilon4/4 according to phenotypes, there were no statistical differences in genotypes between two groups 2) In terms of allele frequency, there were also no statistical differences between two groups CONCLUSION: These results suggest that genotypes and alleles of apolipoprotein E seem to be unrelated to the pathogenesis of schizophrenia.
