Serum C-Reactive Protein Level and its Association with Atrial Fibrillation in Korean Adults.
10.4070/kcj.2005.35.4.309
- Author:
Sang Jun HWANG
1
;
Ki Chul SUNG
;
Yong Su LEE
;
Jang Hyuk YOON
;
Byung Jin KIM
;
Bum Soo KIM
;
Jin Ho KANG
;
Man Ho LEE
;
Jung Ro PARK
;
Dong Keuk KEUM
Author Information
1. Division of Cardiology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea. kcmd.sung@samsung.com
- Publication Type:Original Article
- Keywords:
Atrial fibrillation;
C-reactive protein;
Inflammation
- MeSH:
Adult*;
Atrial Fibrillation*;
C-Reactive Protein*;
Female;
Health Promotion;
Humans;
Hypertension;
Inflammation;
Male;
Recurrence;
Risk Factors;
Stroke
- From:Korean Circulation Journal
2005;35(4):309-314
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND AND OBJECTIVES: Recent studies have implicated inflammation as playing an important role in the occurrence, persistence and recurrence of atrial fibrillation and that C-reactive protein is a useful marker of the inflammation. The purpose of this study is to evaluate the association between serum CRP levels and the risk of atrial fibrillation. SUBJECTS AND METHODS: This study was performed on 9,487 subjects (5,263 men and 4,224 women; mean age: 58.8+/-6.6 years) who underwent medical check-ups at the Health Promotion Center in Kanbuk Samsung Hospital. 9,438 normal control subjects and 49 atrial fibrillation patients were included in the study. The CRP was measured using a highly sensitive Behring Nephelometer II. RESULTS: When comparing the two groups, there were significant differences in age, gender and the presence of hypertension and cerebrovascular accident, and these are the previously known risk factors for atrial fibrillation. After adjustment was made for the clinical significant variables of atrial fibrillation, multiple regression analysis revealed that the hsCRP levels were not associated with the risk for atrial fibrillation (p=0.52). CONCLUSION: The inflammatory markers (CRP, WBC count) were not predictive of a higher risk for atrial fibrillation in the Korean population.
