Effects of Dexamethasone on Neurogenic Bladder in Experimental Autoimmune Encephalomyelitis Rat.
- Author:
Joo Hyun PARK
1
;
Young Jin KO
;
Eun Seok CHOI
;
Hye Won KIM
;
Jong Hyun KIM
;
Se Hoon PARK
Author Information
1. Department of Rehabilitation Medicine, College of Medicine, The Catholic University of Korea. medipsh@hanmail.net
- Publication Type:Original Article
- Keywords:
Experimental autoimmune encephalomyelitis (EAE);
Multiple sclerosis;
Dexamethasone;
Neurogenic bladder;
Cystometrogram
- MeSH:
Animals;
Dexamethasone*;
Encephalomyelitis, Autoimmune, Experimental*;
Female;
Humans;
Models, Animal;
Multiple Sclerosis;
Paralysis;
Rats*;
Urinary Bladder;
Urinary Bladder, Neurogenic*
- From:Journal of the Korean Academy of Rehabilitation Medicine
2003;27(5):682-687
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: We studied effects of dexamethasone on neurogenic bladder and paralysis in experimental autoimmune encephalomyelitis (EAE) rat model for multiple sclerosis. METHOD: Thirty-five female Lewis rats were used in the study. Thirteen rats used as normal cystometrogram controls. Twenty-two rats induced EAE were divided into two groups: ten rats as control and twelve rats as dexamethasone injection group. Bladder dysfunction by cystometrogram, severity of weakness, and duration of paralysis were evaluated every other day after the onset of paralysis. RESULTS: Dexamethasone injection group compared to control group presented short duration of bladder dysfunction (2.5 vs. 4.2 day, p<0.05) and paralysis (4.5 vs. 7.3 day, p<0.05). There was a trend for lesser paralysis in the dexamethasone injection group, than control group (weakness scores were 2.4 vs. 3.6, p>0.05), but it was not statistically significant. CONCLUSION: Dexamethasone ameliorates the course of paralysis and bladder dysfunction in EAE. We suggest that dexamethasone treatment is an effective method in treating neurogenic bladder and paralysis in multiple sclerosis.
