Pain Relief Effect of Calcitonin Injection in Ovariectomized Rats.
- Author:
Jeong Won CHOI
1
;
Jae Soon CHUNG
;
Ki Soeb CHOI
;
Si Bog PARK
;
Sang Gun LEE
;
Mi Jung KIM
Author Information
1. Department of Rehabilitation Medicine, Hanyang University College of Medicine, Korea. gardendsg@hanmail.net
- Publication Type:Original Article
- Keywords:
Ovariectomy;
Calcitonin;
Tail withdrawal test
- MeSH:
Animals;
Calcitonin*;
Control Groups;
Female;
Ovariectomy;
Rats*;
Rats, Sprague-Dawley;
Tail;
Water
- From:Journal of the Korean Academy of Rehabilitation Medicine
2002;26(5):587-590
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: To confirm the effect of calcitonin injection relieving pain in ovariectomized rats. METHOD: Thirty five Sprague-Dawley rats were randomly divided into five groups (high dose calcitonin group (112 U/ Kg), low dose calcitonin group (56 U/Kg), free calcitonin group, ovariectomy group, control group). To assess the pain in ovariectomized rats, the tail of rats were dived in waters of 50+/-1degrees C. Then the tail withdrawal time was measured (tail withdrawal test). The tail withdrawal test was performed in once a week for eight weeks. RESULTS: 1. At seven and eight weeks after injection, the tail withdrawal time of high and low dose calcitonin group compared with that of ovariectomy group were significantly prolonged (p<0.05). 2. At eight weeks after injection, the tail withdrawal time of free calcitonin group compared with that of ovariectomy group was significantly prolonged (p<0.05). CONCLUSION: The effect of calcitonin injection relieving pain in ovariectomized rats was found.
