5% Imiquimod Cream in the Treatment of Bowen's Disease.
- Author:
Kyung Real LEE
1
;
Doo Hwan KIM
;
Moon Soo YOON
Author Information
1. Department of Dermatology, Bundang CHA General Hospital, College of Medicine, Pochon CHA University, Seongnam, Korea. teamdoctor@hanmail.net
- Publication Type:Original Article
- Keywords:
Bowen's disease;
Imiquimod
- MeSH:
Aged;
Appointments and Schedules;
Bowen's Disease*;
Humans;
Recurrence
- From:Korean Journal of Dermatology
2007;45(4):338-344
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Bowen's disease is a challenging condition to treat because lesions often affect the elderly who are usually intolerable to invasive treatment modalities and lesions are often located at sites that heal poorly. OBJECTIVE: The aim of this study was to evaluate the effectiveness and the safety of 5% imiquimod cream for the treatment of Bowen's disease. METHODS: Eleven patients with biopsy-proven Bowen's disease were treated with once-daily or twice-daily self- application of 5% imiquimod cream for a maximum of 16 weeks. RESULTS: Nine of ten (90%) patients who completed the treatment schedule showed complete clinicopathologic regression. One (11%) patient showed recurrence of Bowen's disease on the treated site. 5% imiquimod cream was generally well-tolerated and no serious side effects were observed. CONCLUSION: 5% imiquimod cream appears to be an effective modality for treatment of Bowen's disease and might represent a valuable alternative to surgery or other invasive treatment methods.
