The Cross Effects of Needle Electrical Stimulation according to Electrode Placements on the Analgesia in Arthritic Rat Model.
- Author:
Kyoung Yoon KIM
1
;
Gye Yeop KIM
;
Sung Hwan JUNG
;
Jae Hyung KIM
;
Sam Gyu LEE
Author Information
1. Department of Physical Medicine & Rehabilitation, Research Institutes of Medical Sciences, Chonnam National University Medical School, Korea. sam91@jnu.ac.kr
- Publication Type:Original Article
- Keywords:
Arthritis;
Pain;
Needle electrical stimulation;
Immunohistochemistry;
c-fos expression
- MeSH:
Analgesia*;
Animals;
Arthritis;
Carrageenan;
Electric Stimulation*;
Electrodes*;
Extremities;
Humans;
Immunohistochemistry;
Kaolin;
Knee Joint;
Male;
Models, Animal*;
Needles*;
Rats*;
Rats, Sprague-Dawley
- From:Journal of the Korean Academy of Rehabilitation Medicine
2007;31(2):143-149
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: To investigate the analgesic effect of needle electrical stimulation (NES) according to the electrode placement in acute arthritic rat model. METHOD: Male Sprague-Dawley rats (120 rats, 250+/-50 g) were injected with a mixture of 3% carrageenan and 3% kaolin into the right knee joint. Rats were randomly assigned into one of four groups: Group I, control group (n=30); Group II, arthritic limb-induced control group (n=30); Group III, NES application group on the ipsilateral arthritic limb (n=30); Group IV, NES application group on the contralateral arthritic limb (n=30). We applied the NES (2 Hz, 200micro s, 20 min) to group III and IV. We assessedthe change of paw withdrawal latency (PWL) and the immunoreactivity of c-fos by immunohistochemistry at baseline, 4, 8, 12 and 24 hours after induction of arthritis. RESULTS: NES was more effective in Group III and IV than group II 8 hours after the induction of arthritis (p < 0.001) based on the results of PWLs and c-fos immunoreactivity. The analgesic effects of Group III were greater than those of group IV (p < 0.001). CONCLUSION: Contralateral NES on arthritic limb reduced pain in arthritic rat model as effectively as ipsilateral NES.
