The Expression of HOX D3 and Vascular Endothelial Growth Factor-C in Skin Tumors.
- Author:
Hyung Dong KIM
1
;
Moon Kyun CHO
;
Young Lip PARK
;
Jong Suk LEE
;
Kyu Uang WHANG
Author Information
1. Department of Dermatology, College of Medicine, Soonchunhyang University, Seoul, Korea. topdoctor@naver.com
- Publication Type:Original Article
- Keywords:
Angiogenesis;
HOX D3;
Lymphangiogenesis;
Metastasis;
VEGF-C
- MeSH:
Carcinoma, Basal Cell;
Carcinoma, Squamous Cell;
Endothelial Cells;
Endothelium, Lymphatic;
Hand;
Integrin alphaV;
Keratoacanthoma;
Lymphangiogenesis;
Melanoma;
Neoplasm Metastasis;
Paget Disease, Extramammary;
Plasminogen Activators;
Sensitivity and Specificity;
Skin Neoplasms;
Skin*;
Up-Regulation;
Urokinase-Type Plasminogen Activator;
Vascular Endothelial Growth Factor C*
- From:Korean Journal of Dermatology
2007;45(4):354-361
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: The anatomical relation between a malignant tumor and its vascular and lymphatic bed is an important influencing metastasis. Hox D3 is required for these expressions of integrin alpha v beta3 and urokinase plasminogen activator (uPA), which contribute to endothelial cell adhesion, invasion, and migration during angiogenesis. Recent studies in different tumor types have shown that vascular endothelial growth factor-C (VEGF-C), which displays a high specificity for lymphatic endothelium, is involved in tumor-induced lymphagiogenesis and lymphatic metastatic spread. OBJECTIVE: This study was designed to measure the expression of HOX D3 and VEGF-C in different skin cancers. METHODS: The expression of HOX D3 and VEGF-C was examined by immunohistochemical staining of 40 skin cancer tissue samples, including 8 keratoacanthomas, 8 extramammary paget's disease, 8 basal cell carcinomas, 8 squamous cell carcinomas and 8 malignant melanomas. RESULTS: Immunohistochemical analysis of 40 skin cancer tissue samples revealed a high expression of HOX D3 and VEGF-C in the more aggressive and invasive skin tumors, including squamous cell carcinomas and malignant melanomas. On the other hand, low expression was seen in the less-invasive skin tumors, including keratoacanthomas, extramammary paget's disease and basal cell carcinomas. Also the degree of expression of HOX D3 and VEGF-C showed a statistically-significant correlation with each skin tumor (p<0.05). CONCLUSION: These findings provide evidence that the upregulation of HOX D3 and VEGF-C might be involved in the promotion of angiogenesis and lymphagiogenesis in skin tumors and play an important role in metastasis.
