Findings of Semiquantitative Analysis of 99mTc-HMPAO Brain SPECT in Cerebral Palsy.
- Author:
Eun Seok CHOI
1
;
Seung Han YANG
;
Sae Yoon KANG
;
Si Won KANG
;
Yong Seog KIM
Author Information
1. Department of Rehabilitation Medicine, The Catholic University College of Medicine, Korea.
- Publication Type:Original Article
- Keywords:
Cerebral palsy;
Brain SPECT;
rCBF;
Quantitative analysis;
Topographical involvement
- MeSH:
Brain*;
Cerebral Palsy*;
Child;
Hemiplegia;
Humans;
Technetium Tc 99m Exametazime*;
Tomography, Emission-Computed, Single-Photon*
- From:Journal of the Korean Academy of Rehabilitation Medicine
1997;21(5):841-850
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
It is often difficult, on the basis of clinical examination and conventional investigations, to evaluate the functional impairment of brain in children with cerebral palsy in which early detection remains a challenge. This study was designed to know the usefulness of single photon emission tomography(SPECT) of the brain with technetium-99 m hexamethylpropyleneamineoxime (99mTc-HMPAO) as a semiquantitative method of determination of right-left asymmetries in tracer uptake and a change in antero-posterior regional cerebral blood flow(rCBF) distribution. We investigated 33 children with cerebral palsy aged from 4 months to 48 months(mean 19.3 months). The results were as follows: right to left ratio and regional index of a transverse view were useful to quantify the decrease of tracer uptake in left hemiplegia, but not in right hemiplegia who were all mild in severity, and in tetra- and diplegia in which cerebral lesions were found bilaterally; cortico-cerebellar ratios of a sagittal view were found useful to detect a decrease of rCBF distribution in tetra- and diplegia ,which was not distinct by means of right to left ratio and regional index on transverse view. The results suggest that semiquantitative analysis of 99mTc-HMPAO Brain SPECT would be a valuable complementary tool for determination of topographical involvement in cerebral palsy.
