Electrophysiological Changes after Botulinum Toxin Type A in Children with Cerebral Palsy.
- Author:
Seong Woo KIM
1
;
Jung Bin SHIN
;
Sung YOU
;
Hyoung Seop KIM
;
Ji Hyun NAM
;
Sang Hyuk SONG
Author Information
1. Department of Rehabilitation Medicine, Ilsan Hostpital, National Health Insurance Corporation, Korea. nayanj@freechal.com
- Publication Type:Original Article
- Keywords:
Cerebral palsy;
Spasticity;
Botulinum toxin;
H-reflex;
T-reflex
- MeSH:
Action Potentials;
Animals;
Ankle;
Botulinum Toxins;
Botulinum Toxins, Type A;
Cerebral Palsy;
Child;
H-Reflex;
Humans;
Muscle Spasticity;
Muscles;
Organic Chemicals;
Sural Nerve;
Tibial Nerve
- From:Journal of the Korean Academy of Rehabilitation Medicine
2010;34(2):179-184
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: To investigate the electrophysiological changes after botulinum toxin type A injection in children with cerebral palsy. METHOD: Sixteen children with spastic cerebral palsy enrolled in the study. Botulinum toxin type A (Dysport(R)) was injected into gastrocnemius muscles. Electrophysiological assessments included the compound motor action potential of the tibial nerve, the sensory nerve action potential of the sural nerve, the H-reflex and the T-reflex before injection, and at 2 weeks and 4 weeks after the injection. Modified Ashworth scale was used to evaluate spasticity before, 2 weeks and 4 weeks after the injection. RESULTS: Modified Ashworth scale of the ankle decreased at 2 weeks and 4 weeks after injection. The amplitude of the H-reflex and H(max)/M(max) ratio decreased significantly at 4 weeks. The amplitude of the T-reflex decreased at 2 weeks and 4 weeks. The correlation between changes in modified Ashworth scale of the ankle and the changes in electrophysiological parameters at 4 weeks after injection were not significant. CONCLUSION: The change in T-reflex is faster than the change of H-reflex and H(max)/M(max) ratio after botulinum toxin A injection in children with cerebral palsy. Electrophysiological tests could quantify the change in spasticity after botulinum toxin injection.
