Teicoplanin-induced Elevation of Plasma Creatine Phosphokinase in the Patient with Wound Infection: A case report.
- Author:
Geun Young PARK
1
;
Joo Hyun PARK
;
Yun Hee KIM
;
Sae Hyun KIM
;
Byung Woo YANG
Author Information
1. Department of Rehabilitation Medicine, College of Medicine, The Catholic University of Korea, Korea. rokin98@catholic.ac.kr
- Publication Type:Case Report
- Keywords:
Teicoplanin;
Creatine phosphokinase (CPK);
Pressure sore
- MeSH:
Coccyx;
Creatine;
Creatine Kinase;
Female;
Half-Life;
Humans;
Incidence;
Methicillin-Resistant Staphylococcus aureus;
Persistent Vegetative State;
Plasma;
Pressure Ulcer;
Skin;
Teicoplanin;
Vancomycin;
Wound Infection
- From:Journal of the Korean Academy of Rehabilitation Medicine
2008;32(4):469-471
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The use of teicoplanin is increasing with increase in the incidence of wound infections caused by methicillin-resistant Staphylococcus aureus. Teicoplanin has longer half-life than vancomycin, so it can be administerd once daily, whereas vancomycin has to be administered 3~4 times daily. Teicoplanin is known to have lesser side effect profiles than vancomycin, such as skin eruptions, ototoxicity and nephrotoxicity. A 27-year old women in vegetative state had a grade 3 pressure sore at coccyx area. We prescribe teicoplanin to manage wound infected by methicillin-resistant Staphylococcus aureus. Plasma creatine phosphokinase (CPK) was elevated abruptly at 9th day of teicoplanin therapy. Five days after discontinuation of teicoplanin, CPK was normalized. We experienced a case of elevation of plasma creatine phosphokinase associated with teicoplanin.
