Effects of Growth Hormone Replacement Therapy on Quality of Life in Patients with Somatopause.
- Author:
Sang Beom KIM
1
;
Kyung Hyun RYOO
;
Kisung YOON
;
Kyeong Woo LEE
;
Hyun KWAK
;
Gyu Tae PARK
Author Information
1. Department of Physical Medicine and Rehabilitation, Dong-A University College of Medicine, Korea. ryukh74@nate.com
- Publication Type:Original Article
- Keywords:
Somatopause;
Quality of life;
Growth hormone replacement therapy
- MeSH:
Adult;
Aged;
Growth Hormone*;
Humans;
Prospective Studies;
Quality of Life*;
Surveys and Questionnaires
- From:Journal of the Korean Academy of Rehabilitation Medicine
2007;31(2):202-206
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: There is increasing interest in growth hormone (GH) replacement therapy to improve quality of life (QoL) of elderly with age-related decline in GH level (somatopause). The aim of this study was to evaluate the effect of GH replacement on the QoL in patients with somatopause. METHOD: A prospective study of 56 adults with somatopause was conducted. They were replaced with a GH over a 6-month period. QoL was assessed by using three self-rating questionnaires: the Nottingham Health Profile (NHP), the Psychological General Well-Being Index (PGWBI) and theAssessment of Growth Hormone Deficiency in Adults (AGHDA). RESULTS: Significant impairment in QoL as measured by NHP, PGWBI and AGHDA were noted in patients with somatopause compared with age and sex matched normal population (p<0.05). There was significant improvement in QoL after 6-month of GH replacement (p<0.05). CONCLUSION: Six months GH replacement induced an improvement in the QoL of patients with somatopause.
