Comparison of the Effects between Growth Hormone and Hyaluronic Acid on Degenerative Cartilage of Knee in Rabbit.
- Author:
Sang Beom KIM
1
;
Kyeong Woo LEE
;
Nam Jin HA
;
Jong Hwa LEE
;
Young Dong KIM
;
Yang Lae JOE
;
Dae Chul KIM
Author Information
1. Department of Physical Medicine and Rehabilitation, Dong-A University College of Medicine, Korea. kelee65@dau.ac.kr
- Publication Type:Original Article
- Keywords:
Growth hormone;
Hyaluronic acid;
Degenerative cartilage of knee
- MeSH:
Biological Science Disciplines;
Cartilage;
Growth Hormone;
Hyaluronic Acid;
Injections, Intra-Articular;
Knee;
Rabbits
- From:Journal of the Korean Academy of Rehabilitation Medicine
2008;32(3):247-252
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: To explore whether the growth hormone is effective in the treatment of degenerative cartilage of knee in rabbits. METHOD: Thirty New Zealand white rabbits were administered intra-articular injection with monosodium iodoacetate (Sigma, St. Louis, USA) 2.5 mg and divided into 3 groups. Each group was administered with hyaluronic acid (Hyruan plus(R), LG life science, Seoul, Korea)(group A) 0.6 ml, growth hormone (Declage(R), LG life science, Seoul, Korea) (group B) or saline (group C) 0.6 ml intra-articulary once a week for 4 weeks, beginning 4 weeks after the degeneration induction. All rabbits were killed 9 weeks after degeneration induction. The histologic morphology was observed by optical microscope with knee cartilage. RESULTS: Mankin score was 2.4+/-1.3 in group A, 3.9+/-1.7 in group B, 7.4+/-0.8 in group C. Yoshimi score was 1.5+/-0.7 in group A, 2.2+/-0.9 in group B, 4.4+/-0.6 in group C. Gross and microscopic morphologic findings showed that group C represented the more severe than group A & B (p<0.01), also group A was better than group B (p<0.05). CONCLUSION: Growth hormone is effective on degenerative knee cartilage in rabbit model, but less than the hyaluronic acid.
