Relationship among Estradiol, Lipid Profile, Biochemical Markers, and Bone Mineral Density according to Postmenopausal Period.
- Author:
Ghi Chan KIM
1
;
Ho Joong JEONG
;
Sang Wook JEONG
;
Heung Chae CHUNG
Author Information
1. Department of Rehabilitation Medicine, Kosin University College of Medicine.
- Publication Type:Original Article
- Keywords:
Postmenopausal osteoporosis;
Estradiol;
Osteocalcin;
Deoxypyridinoline;
Bone mineral density
- MeSH:
Alkaline Phosphatase;
Biomarkers*;
Bone Density*;
Estradiol*;
Female;
Humans;
Menopause;
Osteocalcin;
Osteoporosis;
Osteoporosis, Postmenopausal;
Postmenopause*
- From:Journal of the Korean Academy of Rehabilitation Medicine
2000;24(2):318-325
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: To determine whether estradiol (E2), lipid profile, biochemical markers, and bone mineral density (BMD) are related according to postmenopausal period. METHOD: One hundred fifty four women were divided into four groups according to the time past menopause: group I (0~5 years), group II (6~10 years), group III (11~15 years), group IV (more than 16 years). Group I, II, III were subdivided into osteoporosis group (t-score< 2.5) and non-osteoporosis group (t-score> or = 2.5). E2, lipid profile, osteocalcin, alkaline phosphatase, deoxypyridinoline, and BMD by DEXA were measured in all groups. RESULTS: There were significant inverse correlation between BMD and postmenopausal period (p<0.05). Deoxypyridinoline and osteocalcin were correlated with postmenopausal period but there was no statistical significance. Deoxypyridinoline and osteocalcin were increased in osteoporosis group compared to non-osteoporosis group but there was no statistical significance. E2 had significant inverse correlations with postmenopausal period (p<0.05). E2 had no correlation with factors such as biochemical markers and lipid profile in group I, II, III but had adverse correlation with deoxypyridinoline in group IV. CONCLUSION: No specific biochemical markers regarding the duration of menopause were found. Regardless of the duration of menopause, checking both osteocalcin and deoxypyridinoline was statistically significant for the evaluation of postmenopausal osteoporosis.
