Carbamazepine-induced Acute Interstitial Lung Disease.
- Author:
Koo KIM
1
;
Min Jung KANG
;
Kyeong Tae KIM
;
Joon Sang LEE
Author Information
1. Department of Rehabilitation Medicine, Dong-eui Hospital, Korea.
- Publication Type:Case Report
- Keywords:
Carbamazepine;
Acute interstitial lung disease
- MeSH:
Aged;
Carbamazepine;
Consciousness;
Diagnosis;
Dyspnea;
Epinephrine;
Humans;
Lung Diseases;
Lung Diseases, Interstitial*;
Middle Cerebral Artery;
Respiration, Artificial;
Thorax;
Ventilators, Mechanical
- From:Journal of the Korean Academy of Rehabilitation Medicine
2002;26(4):489-491
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Seven days after starting carbamazepine therapy because of a central pain, a 67-year old man with the occlusion of left middle cerebral artery developed acute interstitial lung disease with severe dyspnea and decreased consciousness. Initial therapy included mechanical ventilation, discontinuation of carbamazepine, and injection with epinephrine and steroid. Five days after developing the acute interstitial lung disease, his clinical status and the finding of simple chest X-ray were markedly improved. Several days later, there was the removal of the ventilator and resolution of pulmonary symptoms. Acute interstitial lung disease is a rare fatal adverse reaction to carbamazepine therapy. However, awareness of carbamazepine-induced lung disease may reduce delays in both diagnosis and withdrawal of the drug.
