A Case of Epidermolysis Bullosa Acquisita.
- Author:
Mi Sook CHANG
;
Dae Sung LEE
;
Yung Whan KIM
;
Won HOUH
;
Chang Woo LEE
- Publication Type:Case Report
- Keywords:
Epidermolysis bullosa acquisita;
Subepidermal blisier
- MeSH:
Blister;
Cicatrix;
Epidermis;
Epidermolysis Bullosa Acquisita*;
Epidermolysis Bullosa*;
Female;
Humans;
Membranes;
Middle Aged;
Skin;
Sodium Chloride
- From:Korean Journal of Dermatology
1988;26(4):581-586
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
We report a case of epidermolysis bullosa acquisita in a 53 year-old woman who had. extreme skin fragility, trauma induced blisters and erosions usually localized to extensor site of the skin surface, and healing with scars and milia for several years. Histologic findings of perilesional skin showed normal epidermis, subepid malblister and spirsely infiltration of inflammatory cells. Direct immuncofluorescence showed depositiori of IgCi and C3 in a linear pattern along the epidermal basement, membrane in the per ilesional skin. In indirect immuriofluorescence, using 1.0M sodium chloride separated nor mal human skin as the sntbstrate, antitodies(IgG at a titer of 1:40) were bound to dermal site of the separation, indicating that the patient serum yields the reaction in or below the lamiria densa. Electronmicroscopic findings showed the roof of the blister was located. below the basal lamiria.
