The Effect of Growth Hormone on Bone Mineral Density of the Corticosteroid-Induced Osteoporosis in Rat.
- Author:
Jai Kyun HEO
1
;
Gi Seob CHOI
;
Sang Gun LEE
;
Yong Uk PARK
;
Suk Shin CHO
Author Information
1. Department of Rehabilitation Medicine, College of Medicine, Hanyang University, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Osteoporosis;
Corticosteroid;
Growth hormone;
Bone density;
DXA
- MeSH:
Absorptiometry, Photon;
Animals;
Body Weight;
Bone Density*;
Femur;
Growth Hormone*;
Human Growth Hormone;
Humans;
Male;
Osteoporosis*;
Rats*
- From:Journal of the Korean Academy of Rehabilitation Medicine
1999;23(4):690-694
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: This study was designed to evaluate the effect of growth hormone on bone mineral density of corticosteoid-induced osteoporosis in male rat. METHOD: Twenty Sprague-Dwaley male rats was studied, divided into four group, each group has 5 rats. The group 1 was treated with saline. The group 2 was treated with corticosteroid (Methylprednisolone 10 mg/kg). The group 3 was treated with corticosteroid and growth hormone (recombinant human growth hormone 0.5 IU/kg). The group 4 was treated with growth hormone after corticosteroid treatment. The treatment duration was 6 weeks for each group. After six weeks of hormone administration, the animals were sacrificed, the bilateral femur were removed and tested for bone mineral density using dual energy X-ray absorptiometry and examined histomorphometrically. RESULTS: Administration of growth hormone after corticosteroid therapy, the growth hormone could reverse the decrease in body weight and bone mineral density induced by corticosteroid therapy (p<0.05). CONCLUSION: When growth hormone is administrated after corticosteroid therapy, the growth hormone can protect the osteoporosis in male rats induced by a high dose of corticosteroid.
