Comparing the Effect of Two Doses of Botulinum Toxin A (Dysport(R)) for Treatment of Calf Muscle in Spastic Cerebral Palsy.
- Author:
Moon Suk BANG
1
;
Shi Uk LEE
;
Jin Woo PARK
;
Sang Jun KIM
Author Information
1. Department of Rehabilitation Medicine, Seoul National University College of Medicine, Korea.
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords:
Cerebral palsy;
Dysport;
Calf muscle;
Spasticity
- MeSH:
Ankle;
Botulinum Toxins*;
Cerebral Palsy*;
Child;
Gait;
Humans;
Muscle Spasticity*
- From:Journal of the Korean Academy of Rehabilitation Medicine
2002;26(3):279-284
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: To determine the effective and safe dose of Dysport(R) (one of the commercial botulinum toxins) for relieving the spasticity of calf muscle in cerebral palsy. METHOD: Twenty spastic cerebral palsy children (34 limbs) were randomly assigned to a high dose (HD; 16 Unit/kg/limb) injection group and low dose (LD; 8 Unit/kg/limb) injection group. Locomotor rating scale (LRS) and para meters of 3 dimensional gait analysis including ankle dorsiflexion angle at stance phase (MADA), maximal dynamic gastrocnemius (MDGL) and soleus length (MDSL) were assessed before, 4 weeks after, and 12 weeks after injection. RESULTS: Mean LRS, MADAs, MDGLs and MDSLs were significantly increased both 4 and 12 weeks after injection in HD group. In LD group, LRS, MADAs, MDGLs and MDSLs showed some improvement but they were statistically insignificant. The high dose had no adverse effect except the mild and transient weakness, which was tolerable to the cerebral palsy patients. CONCLUSION: The present study demonstrated the high dose injection of Dysport was more effective than the low dose injection to relieve the spasticity of calf muscle in cerebral palsy.
