Effect of Seizure Disorders on Developmental Disability in Patients with Cerebral Palsy or Delayed Development.
- Author:
Eun Sook PARK
1
;
Chang Il PARK
;
Ji Cheol SHIN
;
In Keol BANG
Author Information
1. Department of Rehabilitation Medicine, Yonsei University College of Medicine.
- Publication Type:Original Article
- Keywords:
Epilepsy;
Neonatal seizure;
Cerebral palsy;
Delayed development;
Bayley Scale Infant Development
- MeSH:
Carbamazepine;
Cerebral Palsy*;
Child;
Child Development;
Developmental Disabilities*;
Electroencephalography;
Epilepsy*;
Humans;
Incidence;
Infant;
Phenobarbital;
Quadriplegia;
Seizures*;
Valproic Acid
- From:Journal of the Korean Academy of Rehabilitation Medicine
1999;23(3):516-523
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: To investigate the effect of epilepsy and neonatal seizure on development in children with cerebral palsy (CP) or delayed development (DD). METHOD: The subjects were 135 patients with CP or DD. Development was evaluated by Bayley Scale of Infant Development II (BSID II). Epilepsy was diagnosed on the base of clinical features, past history and electroencephalography. RESULTS: The incidence of epilepsy was 18.4% in CP, and 37.8% in DD. Spastic quadriplegia of CP has the highest incidence of epilepsy (38.4%). First seizure attack was occurred before 6 months old of age in 66.7% of CP with epilepsy and in 64.3% of DD with epilepsy. The prevailing type of epilepsy was generalized seizure in DD (57.1%), partial seizure in CP (50.0%). The group with epilepsy had lower psychomotor and mental development quotient on BSID II than the group without epilesy (p<0.05). Polytherapy was more used to control epilepsy than monotherapy. Valproate (50.0%), phenobarbital (37.5%), carbamazepine (31.3%) were commonly used drugs for controlling epilepsy. CONCLUSION: The epilpesy has a negative effect on psychomotor and mental development in the children with CP or DD.
