Effects of Continuous Repetitive Transcranial Magnetic Stimulation on Pain Response in Spinal Cord Injured Rat.
- Author:
Young Kyung BAE
1
;
Su Jeong KIM
;
Jeong Min SEO
;
Yun Woo CHO
;
Sang Ho AHN
;
In Soon KANG
;
Hea Woon PARK
;
Se Jin HWANG
Author Information
1. Department of Pathology, College of Medicine, Yeungnam University, Korea.
- Publication Type:Original Article
- Keywords:
Repetitive transcranial magnetic stimulation (rTMS);
Spinal cord injury;
Neuropathic pain;
Cold allodynia
- MeSH:
Animals;
Cold Temperature;
Humans;
Hyperalgesia;
Magnetics;
Magnets;
Neuralgia;
New York;
Rats;
Rats, Sprague-Dawley;
Salicylamides;
Spinal Cord;
Spinal Cord Injuries;
Transcranial Magnetic Stimulation
- From:Journal of the Korean Academy of Rehabilitation Medicine
2010;34(3):259-264
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: To investigate the effects of continuous repetitive transcranial magnetic stimulation (rTMS) on pain response in spinal cord injured rat. METHOD: Forty Sprague-Dawley rats (200~250 grams, female) were used. Thoracic spinal cord (T9) was contused using New York University (NYU) spinal cord impactor. Ten gram weight rod was dropped from a height of 25 mm to produce spinal cord contusion model with moderate injury. The animals were randomly assigned to two groups: one exposed to real magnetic stimulation (real-rTMS group) and the other not exposed to magnetic stimulation (sham-rTMS group). rTMS was applied for 8 weeks. To assess the effect of continuous rTMS on below-level pain responses after spinal cord injury (SCI), the hindpaw withdrawal response for thermal stimuli, cold stimuli and mechanical stimuli were compared between two groups. RESULTS: Behavioral response for pain showed that hindpaw withdrawal response for cold stimuli was reduced significantly from 4 weeks after SCI in real-rTMS group compared with sham group (p<0.05). CONCLUSION: These results suggest that continuous rTMS may have beneficial effects on attenuation of cold allodynia after SCI, and it might be an additional non-invasive therapeutic method in patients with chronic neuropathic pain after SCI.
