Changes in Compound Muscle Action Potentials according to the Dilution Volume of the Botulinum Toxin Type A.
- Author:
Tai Ryoon HAN
1
;
Hyung Ik SHIN
;
Kwang Ho HAN
Author Information
1. Department of Rehabilitation Medicine, Seoul National University College of Medicine.
- Publication Type:Original Article
- Keywords:
Botulinum toxin;
Dilution;
Paralysis;
Compound muscle action potential
- MeSH:
Action Potentials*;
Botulinum Toxins*;
Botulinum Toxins, Type A*;
Healthy Volunteers;
Humans;
Muscles;
Paralysis
- From:Journal of the Korean Academy of Rehabilitation Medicine
2001;25(2):273-277
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: To know if changes in compound muscle action potential (CMAP) of human extensor digitorum brevis (EDB) muscle can be enhanced by increase in dilution volume of botulinum toxin type A. METHOD: In 11 healthy volunteers, 2.5 U of botulinum toxin (Botox (R) , Allergen Inc.) in a volume of 0.1 ml normal saline was injected in EDB muscle and the same dose with the dilution volume of 0.5 ml was injected in the opposite side. We measured the pre- and post-injection M-wave amplitude and area of EDB muscle. RESULTS: The mean post/pre injection amplitude ratio of CMAP were 0.49+/-0.21 with the 0.1 ml of dilution volume and 0.40+/-0.12 with the 0.5 ml of dilution volume. The mean post/pre injection area ratio of CMAP were 0.51 0.18 with the 0.1 ml of dilution volume and 0.44+/-0.15 with the 0.5 ml of dilution volume. There was no significant difference between the two dilution volumes. CONCLUSION: Five fold increase in dilution volume did not enhance the paralyzing effect of botulinum toxin type A in human EDB muscles.
