A Cytogenetic Analysis of Abortus with Spontaneous Abortion.
- Author:
Si Mok HWANG
1
;
Kyung Hun KWON
;
Kyung Ah YOON
;
Sun Kyung OH
Author Information
1. Institute of Reproductive Medicine and Population, Medical Research Center, Seoul National University, Seoul, Korea. gcenter@snu.ac.kr
- Publication Type:Original Article
- Keywords:
Chromosome;
Abortus;
Karyotype
- MeSH:
Abnormal Karyotype;
Abortion, Spontaneous;
Chromosome Aberrations;
Chromosomes, Human, Pair 20;
Chromosomes, Human, Pair 22;
Cytogenetic Analysis;
Cytogenetics;
Down Syndrome;
Female;
Genetic Counseling;
Humans;
Karyotype;
Maternal Age;
Mosaicism;
Pregnancy;
Trisomy
- From:Journal of Genetic Medicine
2009;6(1):62-66
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Chromosomal abnormalities of abortuses have been used to investigate common etiologies of spontaneous abortion, but the frequencies and types of spontaneous abortions have demonstrated considerable variation among different countries and races. MATERIALS AND METHODS: A cytogenetic analysis of 75 abortuses was performed at GenDix, Inc. from January 2006 to December 2007. RESULTS: The frequency of chromosome abnormalities in abortuses was 32.0% (24/75 cases). Among the chromosomal abnormalities, trisomy was present in 62.5% (15/24 cases) of cases and the most frequent trisomy was trisomy 21 with an occurrence rate of 26.6% (4/15 cases). The following was trisomy 22 (3/15 cases) and trisomy 20 (2/15 cases). The average maternal age for abnormal karyotypes was 34.3+/-3.3. CONCLUSION: Cytogenetic analysis of abortus is important for diagnosis and genetic counseling of patients with spontaneous abortion.
