The Preventive Effect of Nimodipine on the Cisplatin Induced Neuropathy.
- Author:
Chang Hwan KIM
1
;
Hyun Chul CHOI
;
Gill Ho ROH
Author Information
1. Department of Rehabilitation Medicine, Inha University College of Medicine, Korea.
- Publication Type:Original Article
- Keywords:
Cisplatin;
Neuropathy;
Nimodipine
- MeSH:
Animals;
Cisplatin*;
Female;
Humans;
Injections, Intraperitoneal;
Neural Conduction;
Nimodipine*;
Peripheral Nervous System Diseases;
Rats;
Sensory Receptor Cells;
Tail;
Weight Loss
- From:Journal of the Korean Academy of Rehabilitation Medicine
2003;27(1):90-95
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: Cisplatin has effectiveness in the treatment of solid tumor by active cytotoxic action, but with significant side effects such as peripheral neuropathy. To investigate the prevention of neuropathy, nimodipine was examined. METHOD: Fifty female rats (Sprague-Dawley strain; BW 210-260 g, 12-15 week old) were used: control group; cisplatin group; cisplatin-nimodipine 2 week group, 10; ciplatin-nimodipine 4 week group; base group. Peripheral neuropathy was induced by intraperitoneal injection of the cisplatin (0.04 mg/ml, 1 ml/kg/ip/ for 2 weeks). Nimodipine was injected intraperitoneally for 2 weeks and 4 weeks in cisplatin-nimodipine 2 week group and cisplatin-nimodipine 4 week group, respectively. Motor and sensory nerve conduction studies were done using in rat tail nerve from the beginning and biweekly till to 10th week. RESULTS: Weight reduction was significant in cisplatin group at 2nd week (p<0.05). The latencies of motor and sensory nerves were delayed in 2nd, 4th week in all groups with cisplatin (p<0.05) and the recovered after 6th week in all groups. The amplitudes of motor and sensory nerves in these groups haven't made any difference compared with control group (p>0.05). CONCLUSION: The neurotoxicity of cisplatin revealed in motor and sensory neurons. The neuropathy has recovered to control value in 6th week and the preventive effect of nimodipine was transient.
