Evidence of Microstructural Abnormality on Descending Motor Pathway in Cerebral Plasied Children with Periventricular Leukomalacia: Diffusion Tensor MRI Study.
- Author:
Zee Ihn LEE
1
;
Sung Min PARK
;
Sang Ho AHN
;
Sung Ho JANG
;
Su Min SON
;
Woo Mok BYUN
Author Information
1. Department of Physical Medicine & Rehabilitation, Daegu Catholic University College of Medicine, Korea.
- Publication Type:Original Article
- Keywords:
Periventricular leukomalacia;
Cerebral palsy;
Diffusion tensor MRI;
Microstructural abnormalities
- MeSH:
Anisotropy;
Brain;
Cerebral Palsy;
Child*;
Diffusion*;
Extremities;
Humans;
Infant, Newborn;
Internal Capsule;
Leukomalacia, Periventricular*;
Magnetic Resonance Imaging*;
Mesencephalon;
Prognosis;
Pyramidal Tracts;
Tegmentum Mesencephali
- From:Journal of the Korean Academy of Rehabilitation Medicine
2003;27(3):340-343
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: Using diffusion tensor MRI (DTI), to investigate the microstructural abnormality of corticospinal tract in the cerebral palsied children with periventricular leukomalacia on conventional MRI and to recognize the clinical usefulness of DTI. METHOD: Seven patients were studied. DTI was peformed using 1.5T MR scanner (Vision Plus, Siemens, Erlangen, Germany) and fractional anisotropies of corona radiata, posterior limbs of internal capsules, and cerebral peduncles of midbrain in both hemisphere were calculated. RESULTS: The fractional anisotropy was significantly decreased in all corona radiata, posterior limbs of internal capsules, cerebral peduncles of midbrain in six patients except one hemiplegic patient, compared with that of control group. In in the hemiplegic patient, the fractional anisotropy was reduced only in affected hemisphere. In addition, the fractional anisotropy tended to be also increased as gross motor function measure (GMFM) score was increased. CONCLUSION: We believe that DTI may be efficient in evaluating microstructural abnormality on the motor pathway of brain and helpful in providing prognosis of clinical findings in cerebral palsied children with periventricular leukomalacia.
