The Effect of Midodrine on Exercise-induced Hypotension in Cervical Cord Injury Patients.
- Author:
Hyun JUNG
1
;
Jeong Hwan SEO
;
Myoung Hwan KO
;
Sung Hee PARK
;
Young Joo SIM
Author Information
1. Department of Physical Medicine and Rehabilitation, Research Institute of Clinical Medicine, Chonbuk National University Medical School, Korea. vivaseo@chonbuk.ac.kr
- Publication Type:Original Article
- Keywords:
Midodrine;
Post-exercise hypotension;
Cervical cord injury
- MeSH:
Arm;
Blood Pressure;
Heart Rate;
Hemodynamics;
Humans;
Hypotension;
Hypotension, Orthostatic;
Midodrine;
Post-Exercise Hypotension;
Spinal Cord Injuries;
Supine Position;
Syncope
- From:Journal of the Korean Academy of Rehabilitation Medicine
2008;32(1):45-50
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: To evaluate the effect of midodrine, an alpha(1) agonist, on symptom and hemodynamic response during standing and arm bicycle ergometer exercise in patients with cervical cord injury. METHOD: Twelve cervical spinal cord injury patients with orthostatic hypotension symptoms and post-exercise hypo- tension were enrolled. They were positioned on a 90degrees standing frame for 3 minutes. After 15 minutes of resting on supine position, 5 minutes of arm bicycle ergometer exercise was done. These tests were done without midodrine initially, but, with 5 mg midodrine on the next day. Heart rate, self-perceived presyncope score (PPS), systolic and diastolic blood pressure were measured before, during and after the exercise. RESULTS: With 5 mg midodrine, the decrease of systolic and diastolic blood pressures after 3 minutes' standing was significantly smaller than without midodrine (p<0.05). PPS was also significantly decreased with midodrine on standing frame test. Arm ergometer exercise induced less systolic blood pressure decrease and better PPS on immediate and 5 minutes after exercise with midodrine (p<0.05). The change of diastolic blood pressure and heart rate was not significant after the exercise with midodrine. CONCLUSION: In cervical spinal cord injury patients with orthostatic and post-exercise hypotension, 5 mg midodrine significantly improved the symptoms and the systolic blood pressures.
