Effect of Stimulation Intensity and Location of Cerebral Infarction on Motor Evoked Potentials in the Rat.
- Author:
Sang Han CHAE
1
;
Hee Chung KWON
;
Jung Keun HYUN
;
Tae Uk KIM
;
Young Il LEE
;
Seong Jae LEE
Author Information
1. Department of Rehabilitation Medicine, Dankook University College of Medicine, Korea. rmlee@dankook.ac.kr
- Publication Type:Original Article
- Keywords:
Motor evoked potentials;
Cerebral ischemia;
Endothelin-1;
Rat
- MeSH:
Animals;
Brain Ischemia;
Cerebral Cortex;
Cerebral Infarction;
Endothelin-1;
Evoked Potentials, Motor;
Forelimb;
Middle Cerebral Artery;
Rats;
Tetrazolium Salts;
Transcranial Magnetic Stimulation
- From:Journal of the Korean Academy of Rehabilitation Medicine
2010;34(4):381-386
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: To investigate the change of motor evoked potential (MEP) in the cerebral infarction, and observe the effect of stimulation intensity and location of cerebral infarction, using rat model of cerebral ischemia induced by endothelin-1 (ET-1). METHOD: Middle cerebral artery (MCA) infarct, cortical infarct, and internal capsular infarct were induced in Spraugue-Dawley rats, by injecting ET-1 stereotaxically. MEP was recorded in forelimb by transcranial magnetic stimulation at 100%, 120%, and 150% of motor threshold by a small figure-8 coil. The location of cerebral infarction was confirmed histologically by 2,3,5-triphenyltetrazolium chloride (TTC) staining. RESULTS: In MCA infarct, MEP was not recorded at all intensity. In internal capsular infarct, no MEP was recorded at 100% of motor threshold, and amplitude was decreased at 120%. In cortical infarct, MEP was not recorded at 100%, but amplitude was maintained at 120% and 150%. Latency did not change significantly at all intensity. CONCLUSION: Amplitude of MEP decreased after cerebral infarction, but latency did not change. Decrease in amplitude was larger with deeper location of cerebral infarction. Cerebral cortex was stimulated at 100% of motor threshold, subcortical structure was stimulated at 120%, and deeper structure was stimulated at 150%, respectively.
