Adverse Side Effect of Baclofen: Case Report.
- Author:
Dong Yen KIM
1
;
Sun Mi CHOI
;
Young Seom KIM
;
Seung Hyun OH
;
Jin LEE
Author Information
1. Department of Rehabilitation Medicine, Presbyterian Medical Center, Chonju, Korea.
- Publication Type:Case Report
- Keywords:
spasticity;
baclofen;
side effect
- MeSH:
Baclofen*;
Butyric Acid;
Creatinine;
Depression;
Filtration;
gamma-Aminobutyric Acid;
Humans;
Muscle Spasticity;
Sleep Stages;
Spinal Cord
- From:Journal of the Korean Academy of Rehabilitation Medicine
1997;21(1):229-233
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Baclofen(B-4-chlorphyl-r-amino butyric acid), a centrally acting gamma amino butyric acid (GABA) agonist is a commonly used pharmaceutics for spasticity of spinal cord lesion. It's effect includes activation of GABA recep tor in primary sensory afferent, enhancement of Ranshow cell activity and depression of fusimotor response. It is primarily excreted by glomerullar filtration with a clearance proportional to creatinine clearance. It's popularity is a result of the antispastic effect and the lack of toxic effect on organ. But, transient drowsiness is the most common neurological side effect with therapeutic dose of the drugs. We report here two patients who developed an acute side effects after being treated with relative therapeutic dose of baclofen.
