Nocturnal Polyuria Developed in Patients with Central Pontine Myelinolysis: A case report.
- Author:
Kwang Lae LEE
1
;
Yoon Myung YIM
;
Oh Kyung LIM
;
Ju Kang LEE
;
Keun Hwan BAE
;
Sung Hwan KIM
;
Chung Hwan CHOI
;
Jeom Sun JEONG
Author Information
1. Department of Rehabilitation, Gachon University of Medicine and Science, Korea. pm@gilhospital.com
- Publication Type:Case Report
- Keywords:
Central pontine myelinolysis;
Nocturnal polyuria;
Antidiuretic hormone
- MeSH:
Brain;
Deamino Arginine Vasopressin;
Demyelinating Diseases;
Follow-Up Studies;
Humans;
Magnetic Resonance Imaging;
Myelinolysis, Central Pontine*;
Osmolar Concentration;
Polyuria*;
Pons;
Urination
- From:Journal of the Korean Academy of Rehabilitation Medicine
2007;31(3):356-360
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Central pontine myelinolysis is a demyelinating disease of central pons. Nocturnal polyuria is defined as increased urination during nighttime with a nocturnal fraction exceeding from 20% to 33%. We have experienced nocturnal polyuria developed in two patients with central pontine myelinolysis. In these cases, serum antidiuretic hormone and urine osmolality were lower at nighttime than daytime. It suggests that nocturnal polyuria is caused by abnormal diurnal variation of antidiuretic hormone. In the first case, nocturnal polyuria was recovered spontaneously and also follow up brain MRI showed decreased signal intensity in pons. In the second case, nocturnal polyuria was improved after the treatment of intranasal desmopressin. It appeares that central pontine myelinolysis can cause nocturnal polyuria due to the interruption of antidiuretic hormone pathway. The symptom of nocturnal polyuria can be treated by desmopressin.
