Multiorgan Thrombotic Occlusions after Acitretin Treatment in a Patient with Chronic Psoriasis: A case report.
- Author:
Chung Yong YANG
1
;
Tae Jin KIM
;
Se Eung NO
;
Min Cheol JOO
;
Eun Young KIL
;
Yong Il SHIN
Author Information
1. Department of Rehabilitation Medicine, Wonkwang University School of Medicine, Institute of Wonkwang Medical Science, Korea. rehab@wonkwang.ac.kr
- Publication Type:Case Report
- Keywords:
Acitretin;
Thrombosis;
Psoriasis
- MeSH:
Acitretin*;
Acute Kidney Injury;
Atherosclerosis;
Cardiovascular System;
Cerebral Infarction;
Drug-Related Side Effects and Adverse Reactions;
Humans;
Infarction;
Leg;
Mesenteric Artery, Superior;
Psoriasis*;
Skin Diseases;
Stroke;
Thrombosis;
Vitamin A
- From:Journal of the Korean Academy of Rehabilitation Medicine
2007;31(3):375-379
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Psoriasis, whose symptom is shown in around 1~3% American people, is a chronic and inflammatory skin disease. There are many treatments for pustular and erythrodermic psoriasis and oral retinoid which is a synthetic derivative of vitamin A is the most popular drug of them. Acitretin called as the second generation retinoid is a kind of active retinoid metabolite, which shows some drug toxicities in hepatic, skeletal and cardiovascular systems including atherosclerosis after a long term use. Even though that, we have just one case which has ever reported on acitretin-associated thrombotic stroke so far. We report a case on a patient who has multiorgan thrombotic occlusions resulted from longstanding psoriatic treatments by using acitretin for five years. This patient suffers from lots of complications such as superior mesenteric artery thrombosis, small cerebellar infarctions, cerebral infarction, acute renal failure concomitant with both small renal infarctions and atherosclerosis obliterans in his two legs.
