Neural Network for Visuospatial Attention in Patients with Traumatic Brain Injury.
- Author:
Yun Hee KIM
1
;
Ji Won PARK
;
Myoung Hwan KO
;
Peter K W LEE
Author Information
1. Department of Physical Medicine & Rehabilitation, Samsung Medical Center & Center for Clinical Medicine, SBRI, Sungkyunkwan University School of Medicine, Korea. yunkim@smc.samsung.co.kr
- Publication Type:Original Article
- Keywords:
Traumatic brain injury;
Visuospatial attention;
Functional magnetic resonance image;
Prefrontal cortex
- MeSH:
Brain;
Brain Injuries*;
Cerebellum;
Frontal Lobe;
Gyrus Cinguli;
Humans;
Magnetic Resonance Imaging;
Prefrontal Cortex;
Reaction Time
- From:Journal of the Korean Academy of Rehabilitation Medicine
2004;28(5):436-443
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To investigate the brain areas related with the deficit in visuospatial attention in patients with traumatic brain injury (TBI) using functional MRI (fMRI). METHOD: Twenty TBI and fifteen normal subjects were enrolled. The endogenous visuospatial attention task was used as an activation paradigm during fMRI. FMRI was performed on a 3T ISOL Forte scanner. Thirty slices were acquired using a single-shot EPI sequences (TR/TE=3000/ 30 ms, Flip angle 70 degrees, FOV=220 mm, 64x64 matrix, slice thickness 4 mm). The accuracy and reaction time to the attention task were measured during fMRI. Imaging data were analyzed using SPM-99 software. RESULTS: The ratio of accurate responses was lower (p<0.01) and the average reaction time was slower (p<0.01) in the TBI group than the normal group. The fMRI analysis showed more activation in the bilateral prefrontal cortices (the middle and inferior frontal gyri) and less activation in the cingulate gyrus, medial frontal lobe, bilateral temporo- occipital areas, and cerebellum in the TBI group compared with the normal group. CONCLUSION: In TBI patients, impaired visuospatial attention might be resulted from the decreased activity of the cingulate, medial frontal, and temporo-occipital regions accompanied with compensatory hyperactivation of the prefrontal cortex.
