The Effect of Peripheral Vascular Disease on Diabetic Neuropathy.
- Author:
Geun Young PARK
1
;
Joo Hyun PARK
;
So Eui LEE
;
Hyun Kyu KANG
;
Myung Eun CHUNG
;
Nam Seok SEONG
Author Information
1. Department of Rehabilitation Medicine, College of Medicine, The Catholic University of Korea. pmr@dreamwiz.com
- Publication Type:Original Article
- Keywords:
Diabetic neuropathy;
Ankle-brachial index;
Toe-brachial index;
Nerve conduction study;
Peripheral vascular disease
- MeSH:
Action Potentials;
Ankle Brachial Index;
Axons;
Diabetes Mellitus;
Diabetic Neuropathies*;
Humans;
Linear Models;
Neural Conduction;
Peripheral Vascular Diseases*;
Sural Nerve;
Ultrasonography
- From:Journal of the Korean Academy of Rehabilitation Medicine
2006;30(1):25-32
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: To evaluate the effect of peripheral vascular disease (PVD) on diabetic neuropathy with the use of Doppler ultrasound and electrodiagnostic study. METHOD: One hundred fifty one patients with diabetes mellitus underwent nerve conduction studies. PVD was diagnosed when ankle-brachial index (ABI) was 0.9 and less and also toe-brachial index (TBI) was 0.7 and less. Electrophysiologically normal group was subdivided into non- PVD group (A1) and PVD group (A2). Diabetic neuropathy group was subdivided into non-PVD group (B1) and PVD group (B2). The frequency of diabetic neuropathy and the difference of amplitude, conduction velocity, and F wave latency within A groups and B groups were investigated. RESULTS: Diabetic neuropathy was significantly correlated with PVD (p<0.05). There was no definite difference of electrophysiologic parameters between A1 and A2 groups. B1 group showed significantly reduced amplitude of sensory nerve action potential (SNAP) in sural nerve compared with B2 group (p<0.05). In all patients, the amplitude of SNAP in sural nerve was related with duration of diabetes and TBI by multiple linear regression analysis. CONCLUSION: This study supports the influence of PVD on diabetic neuropathy and suggests vascular abnormality in patients with diabetic neuropathy may result in predominantly axonal injury rather than demyelinating injury.
