Coagulation Status of the Post-acute Spinal Cord Injured Patients.
- Author:
Jeong Bum SHIN
1
;
Hyun Yoon KO
;
Hyun Joo SOHN
;
Kyung Mi LEE
;
Ji Eui HAN
;
Yong Beom SHIN
;
Jae Hyeok CHANG
;
Ji Sang PARK
Author Information
1. Department of Rehabilitation Medicine, Pusan National University College of Medicine, Korea. yi0314@medimail.co.kr
- Publication Type:Original Article
- Keywords:
Deep vein thrombosis;
Spinal cord injury;
Coagulation status;
Hypercoagulability
- MeSH:
Blood Coagulation;
Diagnosis;
Factor VIII;
Fibrinogen;
Humans;
Incidence;
Prevalence;
Protein C;
Protein S;
Spinal Cord Injuries;
Spinal Cord*;
Spinal Fractures;
Thrombophilia;
Ultrasonography;
Venous Thrombosis
- From:Journal of the Korean Academy of Rehabilitation Medicine
2006;30(6):560-564
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: Deep vein thrombosis (DVT) is one of the most common complications of acute spinal cord injury (SCI). It is well known that the incidence of DVT in post-acute SCI patients decreases to a level similar to that in the general population. The aim of this study was to evaluate the blood coagulation status and the possibility of DVT occurrence in post-acute SCI patients. METHOD: Twenty-three SCI patients (SCI group) were included in this study. Ten patients having spinal fracture with no evidence of SCI were used as the control group. Coagulation status was examined using factor VIII antigen, factor VIII procoagulant, fibrinogen, D-dimer, protein C, and protein S in both groups. Duplex ultrasonography was performed for the diagnosis of DVT. RESULTS: Prevalence of the abnormally decreased protein S level was significantly high in the SCI group (87%) than in the control group (30%). Prevalence of the abnormally increased F VIII:Ag, F VIII:C, and fibrinogen levels in the SCI group were significantly high in the SCI group (p<0.05). CONCLUSION: We conclude that post-acute SCI patients may have hypercoagulability. Proper physical prevention and thromboprophylaxis should be considered in post-acute SCI patients because they have relatively higher risk of thromboembolic complication.
