Association Analyses of beta3AR Trp64Arg and UCP-2 -866G/A Polymorphisms with Body Mass Index in Korean.
10.12701/yujm.2007.24.2.252
- Author:
Hong Soo JUNG
;
Joo Hyun LEE
;
Jun SAKONG
;
Sung Wook BAE
;
Jung Hye KIM
;
Jae Ryong KIM
- Publication Type:Original Article
- Keywords:
Obesity;
Beta-3 adrenergic receptor;
Uncoupling protein 2;
Polymorphism;
Body Mass Index
- MeSH:
Body Mass Index*;
Child;
Fasting;
Glucose;
Humans;
Korea;
Nutrition Disorders;
Obesity;
Phenotype;
Plasma;
Receptors, Adrenergic
- From:Yeungnam University Journal of Medicine
2007;24(2):252-261
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Obesity is the most common nutritional disorder in Western society as well as in Korea. Obesity results from a combination of genetic, environmental, and behavioral factors. MATERIALS AND METHODS: In an attempt to investigate the association of obesity with its candidate genes, beta3 adrenergic receptor (beta3AR) and uncoupling protein 2 (UCP2), we analyzed polymorphisms of beta3AR Trp64Arg and UCP2 -866G/A by PCR-RFLP analysis and the obesity-related phenotypes, including body mass index (BMI), fasting glucose concentration, and plasma lipid profiles in 750 subjects. RESULTS: The Trp64Arg polymorphism in the beta3AR gene was not statistically associated with the BMI. The UCP2 -866G/A polymorphism was significantly higher in obese than in non-obese subjects (P<0.05). However, the UCP2 -866A/A polymorphism was higher in the non-obese subjects. CONCLUSION: These results suggest that the UCP2 -866G/A polymorphism might be more useful for the prediction of obesity and obesity-associated diseases in Korean patients than the beta3AR Trp64Arg polymorphism.
